研究開発
アルツハイマー病の分子病態の解明と臨床応用開発を行っています。
論文リスト
| 著者名 | タイトル | 書誌情報等 | 年 月 |
| Murata, K., Kinoshita,T., Ishikawa, T., Kuroda, K., Hoshi, M., and Fukazawa, Y. | Region- and neuronal- subtype-specific expression of Na, K-ATPase alpha and beta subunit isoforms in the mouse brain | J Comp Neurol. in press. | 2020 |
| Xiao, Y., Matsuda, I., Inoue, M., Sasahara, T., Hoshi, M., and Ishii, Y. | NMR-based site-resolved profiling of β-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril. | J. Biol. Chem. 295, 458-467. | 2020 |
| Komura, H., Kakio, S., Sasahara, T., Arai, Y., Takino, N., Sato, M., Satomura, K., Ohnishi, T., Nabeshima, Y., Muramatsu, S., Kii, I., and Hoshi, M. | Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion | iScience. 13, 452-477 | 2019 |
| Ohnishi, T., Yanazawa, M., Sasahara, T., Kitamura, Y., Hiroaki,H., Fukazawa, Y., Kii, I., Nishiyama, T., Kakita, A., Takeda, H., Takeuchi, A., Arai, Y., Ito, A., Komura, H., Hirao, H., Satomura, K., Inoue, M., Muramatsu, S., Matsui,K., Tada, M., Sato, M., Saijyo, E., Shigemitsu,Y., Sakai,S., Umetsu, Y., Goda,N., Takino,N., Takahashi, H., Hagiwara, M., Sawasaki, T., Iwasaki, G., Nakamura, Y., Nabeshima, Y., Teplow, D.B., and Hoshi, M. | Na,K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly | Proc. Natl. Acad. Sci. USA.112, E4465-E4474 | 2015 |
| Parthasarathy, S., Inoue, M., Xiao, Y., Matsumura, Y., Nabeshima, Y., Long, F., Hoshi, M., and Ishii, Y. | Structural Insight into an Alzheimer’s Brain-Derived Spherical Assembly of Amyloidβ by Solid-state NMR | J. Amer. Chem. Soc. 137, 6480-6483 | 2015 |
| Xiao, Y., Ma. B., McElheny, D., Parthasarathy, S., Long, F., Hoshi, M., Nussinov, R., and Ishii, Y. | Aβ（1-42）fibril structure illuminates self-recognition and replication of amyloid in Alzheimer’s disease | Nature Str. Mol. Biol. 22, 499-505 | 2015 |
| Matsumura, S., Shinoda, K., Yamada, M., Yokojima, S., Inoue, M., Ohnishi, T., Shimada, T., Kikuchi, K., Masui, D., Hashimoto, S., Sato, M., Ito, A., Akioka, M., Takagi, S., Nakamura, Y., Nemoto, K., Hasegawa, Y., Takamoto, H., Inoue, H., Nakamura, S., Nabeshima, Y., Teplow, D.B., Kinjo, M., and Hoshi, M. | Two distinct amyloid β-PROTEIN (Aβ) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology and toxicity analyses | J. Biol. Chem. 286, 11555-11562 |
2011 |
| Hiroaki, H., Umetsu, Y., Nabeshima, Y., Hoshi, M., Kohda, D. | A Simplified Recipe For Assigning Amide NMR Signals Using Combinatorial 14N Amino Acid Inverse-Labeling | J. Struct. Functional Genomics 12, 167-174 |
2011 |
| Roychaudhuri, R., Yang, M., Hoshi, M.M., and Teplow, D.B. | Amyloid β-protein assembly and Alzheimer disease | J. Biol. Chem. 284, 4749-4753 |
2009 |
| Noguchi, A., Matsumura, S., Dezawa, M., Tada, M., Yanazawa, M., Ito, A., Akioka, M., Kikuchi, S., Sato, M., Ideno, S., Noda, M., Fukunari, A., Muramatsu, S., Itokazu, Y., Sato, K., Takahashi, H., Teplow, D.B., Nabeshima, Y., Kakita, A., Imahori, K., and *Hoshi, M. |
Isolation and characterization of patient-derived, toxic, high-mass amyloid β-protein (Aβ) assembly from Alzhiemerʼs disease brains | J. Biol. Chem. 284, 32895-32905 |
2009 |
| Kitamura, Y., Yanazawa, M., Sato, M., Ito, A., and Hoshi, M.M. | Identification of amylospheroid- binding proteins from mature neurons as a molecular target of neurotoxicity induced by nonfibrillar Aβ assemblies | Alzheimer's and Dementia 5, S1, 222-223 |
2009 |
